Gene Information
Gene NameAP2A1
OrganismHomo sapiens (Human)
Gene Length977
Protein NamesAP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000196961 )
Evolutionary StageEukaryota
AlphaFoldDBO95782
Gene CardAP2A1
Uniprot IDO95782
PfamPF01602; PF02296; PF02883
In ASDyes
Allosteric Predictionyes (1.00012413)
Ortholog in AnimalsAlpaca_ AP2A1 ( ortholog_one2one )
Dog_ AP2A1 ( ortholog_one2one )
GuineaPig_ AP2A1 ( ortholog_one2one )
Macaque_ AP2A1 ( ortholog_one2one )
Mouse_ Ap2a1 ( ortholog_one2one )
Pig_ AP2A1 ( ortholog_one2one )
Rat_ Ap2a1 ( ortholog_one2one )
Rabbit_ AP2A1 ( ortholog_one2one )
OhnologsAP2A2
ParalogsAP2A2, AP1G2, AP1G1, AP4E1
TissueNA
Tissue SpecificityExpressed in the brain (at protein level) (PubMed:23676497). Isoform A: Expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon. Isoform B: Widely expressed in tissues and also in breast cancer and in prostate carcinoma cells. {ECO:0000269|PubMed:23676497}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs17851121 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:16262731}. Membrane, coated pit {ECO:0000250};
Peripheral membrane protein {ECO:0000250};
Cytoplasmic side {ECO:0000250}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250}.
Mouse PG classificationNA
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