Gene Information
Gene NameMYH7
OrganismHomo sapiens (Human)
Gene Length1935
Protein NamesMyosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)
Target Namemyosin-7
Target TypeClinical trial target
Gene Age454 ( ENSG00000092054 )
Evolutionary StageCellular_organisms
AlphaFoldDBP12883
Gene CardMYH7
Uniprot IDP12883
PfamPF00063; PF02736; PF01576
In ASDyes
Allosteric Predictionyes (0.999937079)
Ortholog in AnimalsAlpaca_ MYH7 ( ortholog_one2one )
Dog_ MYH7 ( ortholog_one2one )
GuineaPig_ MYH7 ( ortholog_one2one )
Macaque_ MYH7 ( ortholog_one2one )
Mouse_ Myh7 ( ortholog_one2one )
Pig_ MYH7 ( ortholog_one2one )
Rat_ Myh7 ( ortholog_one2one )
Rabbit_ MYH7 ( ortholog_one2one )
OhnologsMYH7B, MYH15
ParalogsMYO3A, MYH10, TMF1, MYO7B, MYO1D, CCDC102B, MYH1, MYO19, MYO1C, MYH3, MYO1A, MYO15A, MYH9, MYO18A, MYO1E, MYH14, MYH2, MYH15, MYO3B, CCDC102A, MYO5A, MYO1G, MYO1H, MYO18B, MYO5C, MYO9B, MYO7A, MYH7B, MYO5B, CGNL1, CGN, MYH11, MYO16, MYO10, MYH8, MYH6, MYO9A, MYO6, MYH4, CCDC158, MYO1B, MYO1F, MYH13
Tissueheart, skeletal.muscle, left.ventricle
Tissue SpecificityBoth wild type and variant Gln-403 are detected in skeletal muscle (at protein level). {ECO:0000269|PubMed:8514894}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.015385(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2FXM  (X-ray  2.70A  )  2FXO  (X-ray  2.50A  )  3DTP  (EM  20.00A  )  4DB1  (X-ray  2.60A  )  4P7H  (X-ray  3.20A  )  4PA0  (X-ray  2.25A  )  4XA1  (X-ray  3.20A  )  4XA3  (X-ray  2.55A  )  4XA4  (X-ray  2.33A  )  4XA6  (X-ray  3.42A  )  5CHX  (X-ray  2.30A  )  5CJ0  (X-ray  2.30A  )  5CJ1  (X-ray  2.10A  )  5CJ4  (X-ray  3.10A  )  5TBY  (EM  20.00A  )  5WJ7  (X-ray  2.50A  )  5WJB  (X-ray  2.90A  )  5WLQ  (X-ray  3.10A  )  5WLZ  (X-ray  3.50A  )  5WME  (X-ray  2.30A  )  6PF2  (X-ray  2.17A  )  6PFP  (X-ray  2.20A  ) 
DBSNP rs3729993  rs186964570  rs376160714  rs771132107  rs2754166  rs397516183  rs1184284157  rs727503278  rs397516209  rs727503278  rs397516212  rs772691929  rs1057517771  rs786205906  rs1057517772  rs730880844  rs1159921588  rs1250974235  rs397516258  rs397516260  rs727504273  rs727503277  rs1060501445  rs121913645  rs1230432463  rs1302598456  rs267606910  rs730880849  rs3218713  rs121913633  rs730880855  rs397516269  rs397515482  rs1244223899  rs376897125  rs1459392243  rs121913640  rs730880864  rs397516088  rs1378946537  rs1275734785  rs121913624  rs121913624  rs3218714  rs730880867  rs730880867  rs1422611896  rs397516095  rs730880868  rs1428725625  rs397516097  rs727503266  rs1566535170  rs1484300349  rs397516098  rs121913653  rs1234112565  rs1403027088  rs1352198296  rs121913625  rs397516101  rs121913625  rs4981473  rs727504236  rs121913651  rs267606911  rs3218715  rs727504286  rs1288878100  rs1333791654  rs397516110  rs121913636  rs863224900  rs727504237  rs121913642  rs1188606962  rs730880879  rs727504238  rs121913626  rs121913626  rs1285747856  rs1381638438  rs1131691685  rs730880880  rs121913627  rs1164270609  rs121913646  rs1241603111  rs397516127  rs371898076  rs727503263  rs727504240  rs886039030  rs730880732  rs397516130  rs1224554825  rs121913638  rs121913641  rs121913637  rs121913630  rs121913630  rs121913644  rs1247313340  rs727504241  rs1173617248  rs863225097  rs727503261  rs121913632  rs121913632  rs786205907  rs397516139  rs730880735  rs727504253  rs121913643  rs727503260  rs1425960124  rs2069544  rs121913634  rs121913634  rs886039185  rs145677314  rs376754645  rs1222361739  rs3218716  rs730880742  rs1373092362  rs1278076805  rs397516149  rs730880748  rs397516155  rs397516157  rs2754158  rs2856897  rs730880750  rs730880750  rs202141173  rs138049878  rs36211715  rs1282663873  rs397516160  rs1314609309  rs397516161  rs1406848007  rs730880757  rs267606908  rs121913631  rs730880759  rs121913628  rs121913628  rs397516170  rs727503252  rs397516171  rs1131691514  rs121913639  rs121913629  rs1391622163  rs755392435  rs1298412196  rs397516179  rs1041961  rs1195446785  rs886039090  rs1170782159  rs397516190  rs758889483  rs141764279  rs727503246  rs45451303  rs397516201  rs397516202  rs730880910  rs201895208  rs145213771  rs397516208  rs1358268382  rs201307101  rs139646545  rs3729823  rs121913647  rs397516222  rs727505176  rs750987717  rs397516232  rs797044601  rs797044602  rs121913650  rs730880916  rs545585809  rs397516241  rs369437262  rs200939753  rs121913654  rs145734640  rs28933098  rs372381770  rs121913652  rs121913649  rs1343372308  rs730880918 
Subcellular location [CC]Cytoplasm, myofibril {ECO:0000250|UniProtKB:P02564}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:P02564}. Note=Thick filaments of the myofibrils. {ECO:0000250|UniProtKB:P02564}.
Mouse PG classificationNA
click here to return to the previous page