| Gene Information | |
|---|---|
| Gene Name | CHGB |
| Organism | Homo sapiens (Human) |
| Gene Length | 677 |
| Protein Names | Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000089199 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P05060 |
| Gene Card | CHGB |
| Uniprot ID | P05060 |
| Pfam | PF01271 |
| In ASD | no |
| Allosteric Prediction | yes (0.261706184) |
| Ortholog in Animals | Alpaca_ CHGB ( ortholog_one2one ) Dog_ CHGB ( ortholog_one2one ) GuineaPig_ CHGB ( ortholog_one2one ) Macaque_ CHGB ( ortholog_one2one ) Mouse_ Chgb ( ortholog_one2one ) Pig_ CHGB ( ortholog_one2one ) Rat_ Chgb ( ortholog_one2one ) Rabbit_ CHGB ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CHGA |
| Tissue | adrenal.gland, pituitary.gland |
| Tissue Specificity | Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver. {ECO:0000269|PubMed:3608978}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs6085324 rs236150 rs6133278 rs910122 rs881118 rs6139873 rs236151 rs236152 rs742710 rs742711 |
| Subcellular location [CC] | Secreted. Note=Neuroendocrine and endocrine secretory granules. |
| Mouse PG classification | NA |
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