| Gene Information | |
|---|---|
| Gene Name | MYBPC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1274 |
| Protein Names | Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform) |
| Target Name | cardiac myosin |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000134571 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14896 |
| Gene Card | MYBPC3 |
| Uniprot ID | Q14896 |
| Pfam | PF00041; PF07679; PF18362 |
| In ASD | no |
| Allosteric Prediction | no (-0.268877838) |
| Ortholog in Animals | Alpaca_ MYBPC3 ( ortholog_one2one ) Dog_ MYBPC3 ( ortholog_one2one ) GuineaPig_ MYBPC3 ( ortholog_one2one ) Macaque_ MYBPC3 ( ortholog_one2one ) Mouse_ Mybpc3 ( ortholog_one2one ) Pig_ MYBPC3 ( ortholog_one2one ) Rat_ Mybpc3 ( ortholog_one2one ) Rabbit_ MYBPC3 ( ortholog_one2one ) |
| Ohnologs | MYBPC2, MYBPC1, MYBPH |
| Paralogs | MYOM1, MYBPC1, MYBPC2, MYBPHL, MYOM3, MYBPH, MYOM2, FNDC3A, OBSL1, IGSF22, FNDC3B |
| Tissue | heart, left.atrium, left.ventricle, mitral.valve, pulmonary.valve, atrium |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GXE (NMR - ) 1PD6 (NMR - ) 2AVG (NMR - ) 2K1M (NMR - ) 2MQ0 (NMR - ) 2MQ3 (NMR - ) 2V6H (X-ray 1.55A ) 3CX2 (X-ray 1.30A ) 5K6P (NMR - ) 6CXI (EM 11.00A ) 6CXJ (EM 11.00A ) 6G2T (EM 9.00A ) 7LRG (EM 6.10A ) |
| DBSNP | rs201278114 rs121909375 rs730880615 rs3729986 rs397516053 rs11570052 rs397516068 rs369300885 rs3729989 rs397516070 rs1444087775 rs890299857 rs397516074 rs373730381 rs397516075 rs376461745 rs147315081 rs375774648 rs11570060 rs727504234 rs34580776 rs573916965 rs730880709 rs1460895809 rs11570076 rs11570077 rs371513491 rs786204338 rs374255707 rs200625851 rs397514752 rs397515905 rs200411226 rs397515907 rs375882485 rs727504287 rs35736435 rs11570082 rs1168604846 rs121909374 rs377163678 rs730880694 rs730880695 rs1172145591 rs376736293 rs778623429 rs1352376969 rs1800565 rs727503191 rs727503191 rs397515956 rs1060501474 rs765629179 rs36211723 rs371488302 rs187830361 rs375675796 rs1338707268 rs727504288 rs2856655 rs199865688 rs3729952 rs752007810 rs371401403 rs371401403 rs35078470 rs121909376 rs193922380 rs376504548 rs11570112 rs727503177 rs727504235 rs3729799 rs397516002 rs371061770 rs11570113 rs1393559112 rs531189495 rs370890951 rs187705120 rs397516026 rs202147520 rs727503167 rs397514751 |
| Subcellular location [CC] | NA |
| Mouse PG classification | HPG |
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