| Gene Information | |
|---|---|
| Gene Name | MXRA5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2828 |
| Protein Names | Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000101825 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | NA |
| Gene Card | MXRA5 |
| Uniprot ID | Q9NR99 |
| Pfam | PF07679; PF13855 |
| In ASD | no |
| Allosteric Prediction | no (-1.184216346) |
| Ortholog in Animals | Dog_ MXRA5 ( ortholog_one2one ) |
| Ohnologs | IGSF10 |
| Paralogs | CNTN5, CNTN2, NFASC, ROBO2, SDK1, SDK2, CNTN3, HMCN2, CNTN6, DSCAML1, VSIG10L, CNTN1, IGDCC4, IGSF21, VCAM1, ROBO1, L1CAM, BOC, DCC, IGDCC3, ROBO4, IGSF9, VSIG10, DSCAM, CDON, NCAM1, ROBO3, CHL1, NRCAM, NEO1, IGSF9B, IGSF10, PTPRQ, NCAM2, PRTG, CNTN4 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in kidney, also detected on liver and spleen (PubMed:27599751). Expressed by proximal tubular cells of the kidney (at protein level) (PubMed:27599751). Expression highly increases during chronic kidney disease and autosomal dominant polycystic kidney disease, where is detected in cysts (PubMed:27599751). {ECO:0000269|PubMed:27599751}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs759222135 rs5983120 rs5983119 rs1635246 rs139106444 rs1726199 rs12396910 rs754393038 rs1974522 rs1635242 rs776590689 rs369042203 rs148675322 rs1726208 rs143264543 rs1419255508 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:27599751}. |
| Mouse PG classification | NA |
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