| Gene Information | |
|---|---|
| Gene Name | MX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 662 |
| Protein Names | Interferon-induced GTP-binding protein Mx1 (Interferon-induced protein p78) (IFI-78K) (Interferon-regulated resistance GTP-binding protein MxA) (Myxoma resistance protein 1) (Myxovirus resistance protein 1) [Cleaved into: Interferon-induced GTP-binding protein Mx1, N-terminally processed] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000157601 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P20591 |
| Gene Card | MX1 |
| Uniprot ID | P20591 |
| Pfam | PF01031; PF00350; PF02212 |
| In ASD | no |
| Allosteric Prediction | yes (0.056512446) |
| Ortholog in Animals | Macaque_ MX1 ( ortholog_one2one ) Mouse_ Mx1 ( ortholog_one2many ) Mouse_ Mx2 ( ortholog_one2many ) Pig_ MX1 ( ortholog_one2one ) Rat_ Mx1 ( ortholog_one2many ) Rat_ Mx2 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | DNM1L, DNM2, OPA1, DNM3, MX2, DNM1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3LJB (X-ray 2.40A ) 3SZR (X-ray 3.50A ) 3ZYS (EM 12.20A ) 4P4S (X-ray 3.30A ) 4P4T (X-ray 2.30A ) 4P4U (X-ray 1.90A ) 5GTM (X-ray 2.90A ) |
| DBSNP | rs469390 rs34717738 rs2230454 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11880649, ECO:0000269|PubMed:21859714, ECO:0000269|PubMed:21992152, ECO:0000269|PubMed:9060610}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15355513, ECO:0000269|PubMed:16413306, ECO:0000269|PubMed:21992152}; Peripheral membrane protein {ECO:0000269|PubMed:16413306}; Cytoplasmic side. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15047845}. Note=Binds preferentially to negatively charged phospholipids (PubMed:21900240). Colocalizes with CCHFV protein N in the perinuclear region (PubMed:15047845). {ECO:0000269|PubMed:15047845, ECO:0000269|PubMed:21900240}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:20603636}. Nucleus {ECO:0000269|PubMed:20603636}. Note=Translocates into the nuclei of HSV-1 infected cells (PubMed:20603636). {ECO:0000269|PubMed:20603636}. |
| Mouse PG classification | NA |
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