| Gene Information | |
|---|---|
| Gene Name | MVP |
| Organism | Homo sapiens (Human) |
| Gene Length | 893 |
| Protein Names | Major vault protein (MVP) (Lung resistance-related protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000013364 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14764 |
| Gene Card | MVP |
| Uniprot ID | Q14764 |
| Pfam | PF11978; PF01505; PF17794; PF17795; PF17796 |
| In ASD | no |
| Allosteric Prediction | yes (0.302695255) |
| Ortholog in Animals | Alpaca_ MVP ( ortholog_one2one ) Dog_ MVP ( ortholog_one2one ) GuineaPig_ MVP ( ortholog_one2one ) Macaque_ MVP ( ortholog_one2one ) Mouse_ Mvp ( ortholog_one2one ) Pig_ MVP ( ortholog_one2one ) Rat_ Mvp ( ortholog_one2one ) Rabbit_ MVP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Y7X (NMR - ) |
| DBSNP | rs35916172 rs3764944 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16441665}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:16441665}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16441665}. Note=5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665). |
| Mouse PG classification | NA |
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