| Gene Information | |
|---|---|
| Gene Name | MUC17 |
| Organism | Homo sapiens (Human) |
| Gene Length | 4493 |
| Protein Names | Mucin-17 (MUC-17) (Small intestinal mucin-3) (MUC-3) |
| Target Name | mucin-17 |
| Target Type | Clinical trial target |
| Gene Age | 244 ( ENSG00000169876 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | NA |
| Gene Card | MUC17 |
| Uniprot ID | Q685J3 |
| Pfam | PF01390 |
| In ASD | no |
| Allosteric Prediction | no (-1.100700378) |
| Ortholog in Animals | Mouse_ Muc3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MUC3A, MUC13 |
| Tissue | duodenum, small.intestine, small.intestine.Peyers.patch |
| Tissue Specificity | Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers. {ECO:0000269|PubMed:11855812, ECO:0000269|PubMed:16737958, ECO:0000269|PubMed:9299468}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs10229731 rs10259584 rs56103274 rs34834039 rs149445753 rs10238201 rs4729646 rs4729647 rs10265276 rs4729652 rs4729651 rs4729653 rs4269454 rs4367469 rs7780935 rs28593004 rs28555173 rs35988443 rs6946812 rs9656065 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass membrane protein.; [Isoform 2]: Secreted {ECO:0000305}. Cell membrane. |
| Mouse PG classification | NA |
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