| Gene Information | |
|---|---|
| Gene Name | MUC16 |
| Organism | Homo sapiens (Human) |
| Gene Length | 14507 |
| Protein Names | Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125) |
| Target Name | mucin-16 |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000181143 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | NA |
| Gene Card | MUC16 |
| Uniprot ID | Q8WXI7 |
| Pfam | PF01390 |
| In ASD | no |
| Allosteric Prediction | no (-0.201073315) |
| Ortholog in Animals | Mouse_ Muc16 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. {ECO:0000269|PubMed:11369781, ECO:0000269|PubMed:12218296, ECO:0000269|PubMed:16384952}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7SA9 (X-ray 1.69A ) |
| DBSNP | rs17000957 rs17000950 rs10411228 rs10406202 rs17000947 rs1596797 rs12611293 rs1596798 rs4520945 rs1108380 rs1574479 rs10407633 rs11085805 rs10410933 rs10416013 rs10402538 rs17000886 rs10407623 rs2591594 rs1559172 rs1559171 rs1862460 rs17000770 rs1867691 rs11670461 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain. |
| Mouse PG classification | NA |
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