Gene Information
Gene NameMUC1
OrganismHomo sapiens (Human)
Gene Length1255
Protein NamesMucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]
Target Namemucin-1
Target TypeNA
Gene Age810 ( ENSG00000185499 )
Evolutionary StageEuk+Bac
AlphaFoldDBP15941
Gene CardMUC1
Uniprot IDP15941
PfamPF01390
In ASDno
Allosteric Predictionno (-0.196484738)
Ortholog in AnimalsAlpaca_ MUC1 ( ortholog_one2one )
Dog_ MUC1 ( ortholog_one2one )
Macaque_ MUC1 ( ortholog_one2one )
Mouse_ Muc1 ( ortholog_one2many )
Rat_ Muc1 ( ortholog_one2many )
Rabbit_ MUC1 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform Y is expressed in tumor cells only. {ECO:0000269|PubMed:15513966, ECO:0000269|PubMed:9212228}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1SM3  (X-ray  1.95A  )  2ACM  (NMR  -  )  2FO4  (X-ray  2.70A  )  5T6P  (X-ray  1.97A  )  5T78  (X-ray  2.20A  )  6FZQ  (X-ray  1.70A  )  6FZR  (X-ray  1.80A  )  6KX1  (X-ray  1.77A  )  6TGG  (X-ray  2.00A  )  7Q4I  (X-ray  2.40A  )  7V4W  (X-ray  2.10A  )  7V64  (X-ray  1.56A  )  7V7K  (X-ray  2.20A  )  7V8Q  (X-ray  3.20A  )  7VAC  (X-ray  3.50A  )  7VAZ  (X-ray  2.73A  ) 
DBSNP rs1611770  rs11465207 
Subcellular location [CC]Apical cell membrane {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402, ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600};
Single-pass type I membrane protein {ECO:0000269|PubMed:11118479, ECO:0000269|PubMed:12832415, ECO:0000269|PubMed:12939402, ECO:0000269|PubMed:15471854, ECO:0000269|PubMed:15972891, ECO:0000269|PubMed:16507569, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:17545600}. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions.;
[Isoform 5]: Secreted.;
[Isoform Y]: Secreted.;
[Isoform 9]: Secreted.;
[Mucin-1 subunit beta]: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus.
Mouse PG classificationNA
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