| Gene Information | |
|---|---|
| Gene Name | RALA |
| Organism | Homo sapiens (Human) |
| Gene Length | 206 |
| Protein Names | Ras-related protein Ral-A (EC 3.6.5.2) |
| Target Name | ras-related protein ral-a |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000006451 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P11233 |
| Gene Card | RALA |
| Uniprot ID | P11233 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | yes (0.175981377) |
| Ortholog in Animals | Alpaca_ RALA ( ortholog_one2one ) Dog_ RALA ( ortholog_one2one ) GuineaPig_ RALA ( ortholog_one2one ) Macaque_ RALA ( ortholog_one2one ) Mouse_ Rala ( ortholog_one2one ) Pig_ RALA ( ortholog_one2one ) Rat_ Rala ( ortholog_one2one ) |
| Ohnologs | RALB |
| Paralogs | RRAS, RHEB, KRAS, DIRAS1, RRAS2, RAP2B, HRAS, RERG, RASL12, RRAD, RIT1, DIRAS2, ERAS, NKIRAS1, RALB, RASD2, GEM, DIRAS3, MRAS, RAP2A, RASD1, REM1, NKIRAS2, RAP1A, RASL11B, RAP1B, RASL10A, RASL11A, REM2, RERGL, RIT2, RHEBL1, NRAS, RAP2C, RASL10B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1UAD (X-ray 2.10A ) 1ZC3 (X-ray 2.00A ) 1ZC4 (X-ray 2.50A ) 2A78 (X-ray 1.81A ) 2A9K (X-ray 1.73A ) 2BOV (X-ray 2.66A ) 6P0I (X-ray 1.18A ) 6P0J (X-ray 1.31A ) 6P0K (X-ray 1.49A ) 6P0L (X-ray 1.30A ) 6P0M (X-ray 1.50A ) 6P0N (X-ray 1.63A ) 6P0O (X-ray 1.54A ) 7NQC (NMR - ) |
| DBSNP | rs1554297905 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17875936, ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925}; Lipid-anchor {ECO:0000269|PubMed:17875936}; Cytoplasmic side. Cleavage furrow {ECO:0000269|PubMed:18756269}. Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Mitochondrion {ECO:0000269|PubMed:21822277}. Note=Predominantly at the cell surface in the absence of LPA. In the presence of LPA, colocalizes with LPAR1 and LPAR2 in endocytic vesicles (PubMed:19306925). May colocalize with CNTRL/centriolin at the midbody ring (PubMed:16213214). However, localization at the midbody at late cytokinesis was not confirmed (PubMed:18756269). Relocalizes to the mitochondrion during mitosis where it regulates mitochondrial fission (PubMed:21822277). {ECO:0000269|PubMed:16213214, ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:21822277}. |
| Mouse PG classification | NA |
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