| Gene Information | |
|---|---|
| Gene Name | MTRR |
| Organism | Homo sapiens (Human) |
| Gene Length | 698 |
| Protein Names | Methionine synthase reductase (MSR) (EC 1.16.1.8) (Aquacobalamin reductase) (AqCbl reductase) |
| Target Name | methionine synthase reductase |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000124275 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UBK8 |
| Gene Card | MTRR |
| Uniprot ID | Q9UBK8 |
| Pfam | PF00667; PF00258; PF00175 |
| In ASD | no |
| Allosteric Prediction | yes (0.300783878) |
| Ortholog in Animals | Alpaca_ MTRR ( ortholog_one2one ) Dog_ MTRR ( ortholog_one2one ) GuineaPig_ MTRR ( ortholog_one2one ) Macaque_ MTRR ( ortholog_one2one ) Mouse_ Mtrr ( ortholog_one2one ) Pig_ MTRR ( ortholog_one2one ) Rat_ Mtrr ( ortholog_one2one ) Rabbit_ MTRR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | POR, NOS1, NDOR1, NOS2, NOS3 |
| Tissue | NA |
| Tissue Specificity | Found in all tissues tested, particularly abundant in skeletal muscle. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2QTL (X-ray 1.90A ) 2QTZ (X-ray 1.90A ) |
| DBSNP | rs1801394 rs761061866 rs1532268 rs2303080 rs10064631 rs162036 rs2287780 rs16879334 rs137853061 rs16879355 rs10380 |
| Subcellular location [CC] | [Isoform B]: Cytoplasm.; [Isoform A]: Cytoplasm {ECO:0000269|PubMed:18221906}. |
| Mouse PG classification | LPG |
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