Gene Information
Gene NameSDR16C5
OrganismHomo sapiens (Human)
Gene Length309
Protein NamesEpidermal retinol dehydrogenase 2 (EPHD-2) (RDH-E2) (EC 1.1.1.105) (Retinal short-chain dehydrogenase reductase 2) (retSDR2) (Short-chain dehydrogenase/reductase family 16C member 5)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000170786 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ8N3Y7
Gene CardSDR16C5
Uniprot IDQ8N3Y7
PfamPF00106
In ASDno
Allosteric Predictionno (-1.061050144)
Ortholog in AnimalsAlpaca_ SDR16C5 ( ortholog_one2one )
Dog_ SDR16C5 ( ortholog_one2one )
GuineaPig_ SDR16C5 ( ortholog_one2one )
Macaque_ SDR16C5 ( ortholog_one2one )
Mouse_ Sdr16c5 ( ortholog_one2one )
Pig_ SDR16C5 ( ortholog_one2one )
Rat_ Sdr16c5 ( ortholog_one2one )
Rabbit_ SDR16C5 ( ortholog_one2one )
OhnologsNA
ParalogsSDR9C7, HSD17B14, HSD17B7, HSD11B2, DHRS12, RDH12, HSDL1, HSD17B4, DHRS9, RDH11, RDH16, HSD17B8, HSD17B11, BDH1, WWOX, HSD17B2, RDH5, DHRS3, HSD17B13, HSD17B12, HSD17B1, RDH10, HSD17B10, HSD17B3, HSD17B6
Tissueesophagus, lung, skin, tonsil, tongue, zone.of.skin, esophagus.mucosa, lower.leg.skin, suprapubic.skin
Tissue SpecificityDetected in adult lung. Detected at low levels in adult brain, heart, testis, placenta, cervix, pancreas, uterus, stomach, rectum, small intestine, colon, esophagus, thymus, skin, and skin keratinocyte. Expression is higher in psoriasis lesions relative to unaffected skin from psoriasis patients. Detected in fetal kidney, skin and lung. {ECO:0000269|PubMed:12372410}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs4151643 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:18926804};
Multi-pass membrane protein {ECO:0000255}.
Mouse PG classificationNA
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