| Gene Information | |
|---|---|
| Gene Name | MTREX |
| Organism | Homo sapiens (Human) |
| Gene Length | 1042 |
| Protein Names | Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000039123 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P42285 |
| Gene Card | MTREX |
| Uniprot ID | P42285 |
| Pfam | PF00270; PF08148; PF00271; PF13234 |
| In ASD | no |
| Allosteric Prediction | no (-0.920190213) |
| Ortholog in Animals | Alpaca_ MTREX ( ortholog_one2one ) Dog_ MTREX ( ortholog_one2one ) GuineaPig_ MTREX ( ortholog_one2one ) Macaque_ MTREX ( ortholog_one2one ) Mouse_ Mtrex ( ortholog_one2one ) Pig_ MTREX ( ortholog_one2one ) Rat_ Mtrex ( ortholog_one2one ) Rabbit_ MTREX ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SKIV2L, SNRNP200, DDX60, DDX60L, HELQ, ASCC3, POLQ, HFM1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.192321(Chimpanzee);0.121698(Mouse);NULL(Rat);0.068945(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6C90 (X-ray 2.20A ) 6D6Q (EM 3.45A ) 6D6R (EM 3.45A ) 6IEG (X-ray 3.55A ) 6IEH (X-ray 2.89A ) 6RO1 (X-ray 3.07A ) 7S7B (EM 4.06A ) 7S7C (EM 3.62A ) 7Z4Y (EM 4.50A ) 7Z4Z (EM 4.00A ) 7Z52 (EM 3.40A ) |
| DBSNP | rs35643285 |
| Subcellular location [CC] | Nucleus, nucleoplasm {ECO:0000269|PubMed:30842217}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:16782053}. Nucleus speckle {ECO:0000269|PubMed:30842217}. |
| Mouse PG classification | NA |
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