| Gene Information | |
|---|---|
| Gene Name | MTR |
| Organism | Homo sapiens (Human) |
| Gene Length | 1265 |
| Protein Names | Methionine synthase (MS) (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Cobalamin-dependent methionine synthase) (Vitamin-B12 dependent methionine synthase) |
| Target Name | methionine synthase |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000116984 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q99707 |
| Gene Card | MTR |
| Uniprot ID | Q99707 |
| Pfam | PF02310; PF02607; PF02965; PF00809; PF02574 |
| In ASD | no |
| Allosteric Prediction | yes (0.73926707) |
| Ortholog in Animals | Alpaca_ MTR ( ortholog_one2one ) Dog_ MTR ( ortholog_one2one ) GuineaPig_ MTR ( ortholog_one2one ) Macaque_ MTR ( ortholog_one2one ) Mouse_ Mtr ( ortholog_one2one ) Pig_ MTR ( ortholog_one2one ) Rat_ Mtr ( ortholog_one2one ) Rabbit_ MTR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BHMT2, BHMT, MTHFR, UROD |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed at the highest levels in pancreas, heart, brain, skeletal muscle and placenta (PubMed:8968737, PubMed:8968735). Expressed at lower levels in lung, liver and kidney (PubMed:8968737, PubMed:8968735). {ECO:0000269|PubMed:8968735, ECO:0000269|PubMed:8968737}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2O2K (X-ray 1.60A ) 4CCZ (X-ray 2.70A ) |
| DBSNP | rs12749581 rs1140598 rs2229274 rs1805087 rs121913579 rs121913578 |
| Subcellular location [CC] | Cytoplasm {ECO:0000305|PubMed:27771510}. |
| Mouse PG classification | NA |
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