| Gene Information | |
|---|---|
| Gene Name | CEACAM3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 252 |
| Protein Names | Carcinoembryonic antigen-related cell adhesion molecule 3 (Carcinoembryonic antigen CGM1) (CD antigen CD66d) |
| Target Name | carcinoembryonic antigen cgm1 |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000170956 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P40198 |
| Gene Card | CEACAM3 |
| Uniprot ID | P40198 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | yes (0.256432355) |
| Ortholog in Animals | Alpaca_ CEACAM3 ( ortholog_one2one ) Dog_ CEACAM1 ( ortholog_many2many ) Mouse_ Ceacam10 ( ortholog_many2many ) Mouse_ Ceacam1 ( ortholog_many2many ) Mouse_ Ceacam2 ( ortholog_many2many ) Rat_ Ceacam1 ( ortholog_many2many ) Rat_ Ceacam4 ( ortholog_many2many ) Rat_ Ceacam6 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | CEACAM19, HEPACAM2, HEPACAM, VSTM5, CEACAM1, CEACAM6, CEACAM5, CEACAM7, CEACAM8, PSG1, PSG8, PSG9, PSG3, PSG7, PSG11, PSG2, PSG4, PSG5, PSG6, CEACAM4, CEACAM21, CEACAM16, CEACAM20, CEACAM18 |
| Tissue | appendix, bone.marrow, whole.blood |
| Tissue Specificity | CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. {ECO:0000269|PubMed:11708798}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6AVZ (X-ray 2.05A ) 6AW0 (X-ray 2.43A ) 6AW1 (X-ray 2.10A ) 6AW3 (X-ray 2.66A ) |
| DBSNP | rs1041999 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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