| Gene Information | |
|---|---|
| Gene Name | MTNR1B |
| Organism | Homo sapiens (Human) |
| Gene Length | 362 |
| Protein Names | Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor) |
| Target Name | melatonin receptor type 1b |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000134640 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P49286 |
| Gene Card | MTNR1B |
| Uniprot ID | P49286 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.597196212) |
| Ortholog in Animals | Alpaca_ MTNR1B ( ortholog_one2one ) Dog_ MTNR1B ( ortholog_one2one ) GuineaPig_ MTNR1B ( ortholog_one2one ) Mouse_ Mtnr1b ( ortholog_one2one ) Pig_ MTNR1B ( ortholog_one2one ) Rat_ Mtnr1b ( ortholog_one2one ) Rabbit_ MTNR1B ( ortholog_one2one ) |
| Ohnologs | GPR50, MTNR1A |
| Paralogs | TACR2, OR9A2, NPY1R, OR11H6, OR11H7, OR11H4, OR9A1P, OR9G1, NPY2R, MTNR1A, GPR50, GPR75, OR11G2, MCHR2, MCHR1, GPR19, OR11A1, TACR1, TACR3, OR11H2, OR11H12, OR11H1, GPR83, PROKR2, PROKR1, GPR88, PRLHR, OR51F1, OR10X1, NPY5R, OR9A4, NPY4R2, NPY4R |
| Tissue | NA |
| Tissue Specificity | Expressed in retina and less in brain and hippocampus. {ECO:0000269|PubMed:7568007}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6ME6 (X-ray 2.80A ) 6ME7 (X-ray 3.20A ) 6ME8 (X-ray 3.10A ) 6ME9 (X-ray 3.30A ) 7VH0 (EM 3.46A ) |
| DBSNP | rs8192552 rs370338802 rs8192553 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
| click here to return to the previous page | |