| Gene Information | |
|---|---|
| Gene Name | MTMR8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 549 |
| Protein Names | Myotubularin-related protein 9 (Inactive phosphatidylinositol 3-phosphatase 9) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000102043 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96QG7 |
| Gene Card | MTMR9 |
| Uniprot ID | Q96QG7 |
| Pfam | PF06602 |
| In ASD | no |
| Allosteric Prediction | no (-0.885820753) |
| Ortholog in Animals | Alpaca_ MTMR8 ( ortholog_one2one ) Macaque_ MTMR8 ( ortholog_one2one ) Pig_ MTMR8 ( ortholog_one2one ) Rabbit_ MTMR8 ( ortholog_one2one ) |
| Ohnologs | MTMR7, MTMR6 |
| Paralogs | MTMR10, MTMR7, SBF1, SBF2, MTMR9, MTM1, MTMR6, MTMR12, MTMR2, MTMR1, MTMR11, MTMR3, MTMR4 |
| Tissue | NA |
| Tissue Specificity | Expressed in many tissues. {ECO:0000269|PubMed:11472061}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001990(Rat);0.114286(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:19038970}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9Z2D0}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:19038970}. Endoplasmic reticulum {ECO:0000269|PubMed:19038970}. Note=Localizes to ruffles during EGF-induced macropinocytosis (By similarity). Colocalizes with MTMR6 to the perinuclear region (PubMed:19038970). Partially localizes to the endoplasmic reticulum (PubMed:19038970). {ECO:0000250|UniProtKB:Q9Z2D0, ECO:0000269|PubMed:19038970}. |
| Mouse PG classification | NA |
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