| Gene Information | |
|---|---|
| Gene Name | MTMR6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 621 |
| Protein Names | Myotubularin-related protein 6 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000139505 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y217 |
| Gene Card | MTMR6 |
| Uniprot ID | Q9Y217 |
| Pfam | PF06602 |
| In ASD | no |
| Allosteric Prediction | no (-0.229925525) |
| Ortholog in Animals | Alpaca_ MTMR6 ( ortholog_one2one ) Dog_ MTMR6 ( ortholog_one2one ) GuineaPig_ MTMR6 ( ortholog_one2one ) Macaque_ MTMR6 ( ortholog_one2one ) Mouse_ Mtmr6 ( ortholog_one2one ) Pig_ MTMR6 ( ortholog_one2one ) Rat_ Mtmr6 ( ortholog_one2one ) Rabbit_ MTMR6 ( ortholog_one2one ) |
| Ohnologs | MTMR8, MTMR7 |
| Paralogs | MTMR10, MTMR7, SBF1, SBF2, MTMR9, MTM1, MTMR8, MTMR12, MTMR2, MTMR1, MTMR11, MTMR3, MTMR4 |
| Tissue | NA |
| Tissue Specificity | Expressed in CD4+ T-cells. {ECO:0000269|PubMed:16847315}. |
| Pharmacological Animal Models | 0.044130(Chimpanzee);NULL(Mouse);NULL(Rat);0.040000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2YF0 (X-ray 2.65A ) |
| DBSNP | rs34885345 rs7995033 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19038970}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:16787938, ECO:0000269|PubMed:19038970}. Endoplasmic reticulum {ECO:0000269|PubMed:19038970}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q8VE11}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19038970}. Note=Localizes to ruffles during EGF-induced macropinocytosis (By similarity). Colocalizes with MTMR9 to the perinuclear region (PubMed:19038970). Partially localizes to the endoplasmic reticulum (PubMed:19038970). Co-localizes with RAB1B to the endoplasmic reticulum-Golgi intermediate compartment and to the peri-Golgi region (By similarity). {ECO:0000250|UniProtKB:A0A0G2JXT6, ECO:0000250|UniProtKB:Q8VE11, ECO:0000269|PubMed:19038970}. |
| Mouse PG classification | NA |
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