Gene Information
Gene NameNTRK1
OrganismHomo sapiens (Human)
Gene Length796
Protein NamesHigh affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Target Nametropomyosin-related kinase a
Target TypeSuccessful target
Gene Age454 ( ENSG00000198400 )
Evolutionary StageVertebrata
AlphaFoldDBP04629
Gene CardNTRK1
Uniprot IDP04629
PfamPF13855; PF16920; PF07714; PF18613
In ASDyes
Allosteric Predictionyes (2.538987698)
Ortholog in AnimalsAlpaca_ NTRK1 ( ortholog_one2one )
Dog_ NTRK1 ( ortholog_one2one )
GuineaPig_ NTRK1 ( ortholog_one2one )
Macaque_ NTRK1 ( ortholog_one2one )
Mouse_ Ntrk1 ( ortholog_one2one )
Pig_ NTRK1 ( ortholog_one2one )
Rat_ Ntrk1 ( ortholog_one2one )
Rabbit_ NTRK1 ( ortholog_one2one )
OhnologsMUSK, NTRK3, NTRK2
ParalogsEPHA7, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET
TissueNA
Tissue SpecificityIsoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. {ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:8325889}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.070588(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1HE7  (X-ray  2.00A  )  1SHC  (NMR  -  )  1WWA  (X-ray  2.50A  )  1WWW  (X-ray  2.20A  )  2IFG  (X-ray  3.40A  )  2N90  (NMR  -  )  4AOJ  (X-ray  2.75A  )  4CRP  (NMR  -  )  4F0I  (X-ray  2.30A  )  4GT5  (X-ray  2.40A  )  4PMM  (X-ray  2.00A  )  4PMP  (X-ray  1.80A  )  4PMS  (X-ray  2.80A  )  4PMT  (X-ray  2.10A  )  4YNE  (X-ray  2.02A  )  4YPS  (X-ray  2.10A  )  5H3Q  (X-ray  2.10A  )  5I8A  (X-ray  2.33A  )  5JFS  (X-ray  2.07A  )  5JFV  (X-ray  1.59A  )  5JFW  (X-ray  1.52A  )  5JFX  (X-ray  1.63A  )  5KMI  (X-ray  1.87A  )  5KMJ  (X-ray  2.04A  )  5KMK  (X-ray  2.24A  )  5KML  (X-ray  2.01A  )  5KMM  (X-ray  2.12A  )  5KMN  (X-ray  2.14A  )  5KMO  (X-ray  2.67A  )  5KVT  (X-ray  2.45A  )  5WR7  (X-ray  2.76A  )  6D1Y  (X-ray  1.93A  )  6D1Z  (X-ray  1.87A  )  6D20  (X-ray  1.94A  )  6D22  (X-ray  2.46A  )  6DKB  (X-ray  2.68A  )  6DKG  (X-ray  2.53A  )  6DKI  (X-ray  2.11A  )  6DKW  (X-ray  2.91A  )  6IQN  (X-ray  2.54A  )  6J5L  (X-ray  2.30A  )  6NPT  (X-ray  2.19A  )  6NSP  (X-ray  2.31A  )  6NSS  (X-ray  1.97A  )  6PL1  (X-ray  2.03A  )  6PL2  (X-ray  2.59A  )  6PL3  (X-ray  3.00A  )  6PL4  (X-ray  2.06A  )  6PMA  (X-ray  2.53A  )  6PMB  (X-ray  2.81A  )  6PMC  (X-ray  2.19A  )  6PME  (X-ray  3.00A  )  7N3T  (X-ray  1.84A  )  7XAF  (X-ray  3.00A  ) 
DBSNP rs201472270  rs1007211  rs55891455  rs543320028  rs540521894  rs747711259  rs55909005  rs56000394  rs35116695  rs121964869  rs56320207  rs34900547  rs144901788  rs606231467  rs1571699266  rs55892037  rs121964866  rs121964870  rs6336  rs6339  rs786205449  rs369353892  rs764992664  rs80356677  rs121964868  rs770727871  rs1324983370  rs35669708  rs35669708  rs55948542 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:1281417, ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:17196528, ECO:0000269|PubMed:27676246, ECO:0000269|PubMed:2927393};
Single-pass type I membrane protein {ECO:0000269|PubMed:1281417, ECO:0000269|PubMed:15488758}. Early endosome membrane {ECO:0000250|UniProtKB:P35739};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P35739}. Late endosome membrane {ECO:0000250|UniProtKB:P35739};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P35739}. Recycling endosome membrane {ECO:0000250|UniProtKB:P35739};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P35739}. Note=Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes. {ECO:0000250|UniProtKB:P35739, ECO:0000269|PubMed:1281417}.
Mouse PG classificationNA
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