| Gene Information | |
|---|---|
| Gene Name | POLQ |
| Organism | Homo sapiens (Human) |
| Gene Length | 2590 |
| Protein Names | DNA polymerase theta (EC 2.7.7.7) (DNA polymerase eta) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000051341 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O75417 |
| Gene Card | POLQ |
| Uniprot ID | O75417 |
| Pfam | PF00270; PF00476; PF00271; PF20470 |
| In ASD | yes |
| Allosteric Prediction | no (-0.207680512) |
| Ortholog in Animals | Alpaca_ POLQ ( ortholog_one2one ) Dog_ POLQ ( ortholog_one2one ) Macaque_ POLQ ( ortholog_one2one ) Mouse_ Polq ( ortholog_one2one ) Pig_ POLQ ( ortholog_one2one ) Rat_ Polq ( ortholog_one2one ) Rabbit_ POLQ ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SKIV2L, SNRNP200, DDX60, DDX60L, HELQ, ASCC3, MTREX, HFM1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in testis. {ECO:0000269|PubMed:14576298}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4X0P (X-ray 3.91A ) 4X0Q (X-ray 3.90A ) 5A9F (X-ray 3.20A ) 5A9J (X-ray 3.55A ) 5AGA (X-ray 2.90A ) |
| DBSNP | rs34778629 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:O18475}. Chromosome {ECO:0000269|PubMed:25642963}. Note=Enriched in chromatin in response to ultaviolet (UV) light (PubMed:25642963). Binds to chromatin during early G1 (PubMed:24989122). {ECO:0000269|PubMed:24989122, ECO:0000269|PubMed:25642963}. |
| Mouse PG classification | NA |
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