| Gene Information | |
|---|---|
| Gene Name | TAB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 504 |
| Protein Names | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) |
| Target Name | tgf-beta-activated kinase 1 and map3k7-binding protein 1 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000100324 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15750 |
| Gene Card | TAB1 |
| Uniprot ID | Q15750 |
| Pfam | PF00481 |
| In ASD | no |
| Allosteric Prediction | yes (0.599165946) |
| Ortholog in Animals | Alpaca_ TAB1 ( ortholog_one2one ) Dog_ TAB1 ( ortholog_one2one ) GuineaPig_ TAB1 ( ortholog_one2one ) Macaque_ TAB1 ( ortholog_one2one ) Mouse_ Tab1 ( ortholog_one2one ) Pig_ TAB1 ( ortholog_one2one ) Rat_ Tab1 ( ortholog_one2one ) Rabbit_ TAB1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PDP2, ILKAP, PPM1B, PPM1L, PPM1N, PP2D1, PDP1, PPM1A, PPM1D, PPM1E, PPM1G, PPM1H, PPM1J, PPM1M, PPM1F, PPM1K |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.019569(Mouse);NULL(Rat);0.038095(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2J4O (X-ray 2.25A ) 2POM (X-ray 2.27A ) 2POP (X-ray 3.10A ) 2YDS (X-ray 2.55A ) 2YIY (X-ray 2.49A ) 4AY5 (X-ray 3.15A ) 4AY6 (X-ray 3.30A ) 4GS6 (X-ray 2.20A ) 4KA3 (X-ray 2.71A ) 4L3P (X-ray 2.68A ) 4L52 (X-ray 2.54A ) 4L53 (X-ray 2.55A ) 4O91 (X-ray 2.39A ) 5DIY (X-ray 2.06A ) 5E7R (X-ray 2.11A ) 5GJD (X-ray 2.79A ) 5GJF (X-ray 2.89A ) 5GJG (X-ray 2.61A ) 5J7S (X-ray 2.37A ) 5J8I (X-ray 2.40A ) 5J9L (X-ray 2.75A ) 5JGA (X-ray 2.00A ) 5JGB (X-ray 2.80A ) 5JGD (X-ray 3.10A ) 5JH6 (X-ray 2.37A ) 5JK3 (X-ray 2.37A ) 5NZZ (X-ray 2.60A ) 5O90 (X-ray 2.49A ) 5V5N (X-ray 2.01A ) 5VVU (X-ray 2.70A ) 7NTH (X-ray 1.97A ) 7NTI (X-ray 1.98A ) |
| DBSNP | rs17001096 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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