| Gene Information | |
|---|---|
| Gene Name | XPNPEP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 507 |
| Protein Names | Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000196236 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9NQH7 |
| Gene Card | XPNPEP3 |
| Uniprot ID | Q9NQH7 |
| Pfam | PF05195; PF00557 |
| In ASD | no |
| Allosteric Prediction | no (-0.990844217) |
| Ortholog in Animals | Alpaca_ XPNPEP3 ( ortholog_one2one ) Dog_ XPNPEP3 ( ortholog_one2one ) GuineaPig_ XPNPEP3 ( ortholog_one2one ) Macaque_ XPNPEP3 ( ortholog_one2one ) Mouse_ Xpnpep3 ( ortholog_one2one ) Pig_ XPNPEP3 ( ortholog_one2one ) Rat_ Xpnpep3 ( ortholog_one2one ) Rabbit_ XPNPEP3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | XPNPEP1, METAP1D, PA2G4, XPNPEP2, METAP2, METAP1, PEPD |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant. {ECO:0000269|PubMed:15708373}. |
| Pharmacological Animal Models | 0.100380(Chimpanzee);NULL(Mouse);NULL(Rat);0.020000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5X49 (X-ray 1.65A ) |
| DBSNP | rs17002243 rs267607179 |
| Subcellular location [CC] | [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:20179356, ECO:0000269|PubMed:25609706}. Cytoplasm {ECO:0000269|PubMed:25609706}. Note=Mainly mitochondrial. Translocates to the cytoplasm following TNFRSF1B activation. {ECO:0000269|PubMed:25609706}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:25609706}. |
| Mouse PG classification | NA |
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