| Gene Information | |
|---|---|
| Gene Name | GRN |
| Organism | Homo sapiens (Human) |
| Gene Length | 593 |
| Protein Names | Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000030582 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P28799 |
| Gene Card | GRN |
| Uniprot ID | P28799 |
| Pfam | PF00396 |
| In ASD | no |
| Allosteric Prediction | yes (0.388056404) |
| Ortholog in Animals | Alpaca_ GRN ( ortholog_one2one ) Dog_ GRN ( ortholog_one2one ) GuineaPig_ GRN ( ortholog_one2one ) Macaque_ GRN ( ortholog_one2one ) Mouse_ Grn ( ortholog_one2one ) Pig_ GRN ( ortholog_one2one ) Rat_ Grn ( ortholog_one2one ) Rabbit_ GRN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1G26 (NMR - ) 2JYE (NMR - ) 2JYT (NMR - ) 2JYU (NMR - ) 2JYV (NMR - ) 6NUG (NMR - ) |
| DBSNP | rs63751243 rs63750723 rs1555610922 rs199944486 rs758168578 rs63750043 rs63750479 rs758322775 rs529849967 rs143030899 rs148213321 rs114248177 rs25647 rs971443926 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:21092856, ECO:0000269|PubMed:26370502}. Lysosome {ECO:0000269|PubMed:21092856, ECO:0000269|PubMed:26370502, ECO:0000269|PubMed:28073925, ECO:0000269|PubMed:28541286, ECO:0000269|PubMed:28743268}. Note=Endocytosed by SORT1 and delivred to lysosomes (PubMed:21092856, PubMed:28073925). Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (PubMed:26370502, PubMed:28073925). Co-localized with GBA1 in the intracellular trafficking compartments until to lysosome (By similarity). {ECO:0000250|UniProtKB:P28798, ECO:0000269|PubMed:21092856, ECO:0000269|PubMed:26370502, ECO:0000269|PubMed:28073925}. |
| Mouse PG classification | NA |
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