| Gene Information | |
|---|---|
| Gene Name | RNF216 |
| Organism | Homo sapiens (Human) |
| Gene Length | 866 |
| Protein Names | E3 ubiquitin-protein ligase RNF216 (EC 2.3.2.27) (RING finger protein 216) (RING-type E3 ubiquitin transferase RNF216) (Triad domain-containing protein 3) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000011275 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NWF9 |
| Gene Card | RNF216 |
| Uniprot ID | Q9NWF9 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.893314412) |
| Ortholog in Animals | Alpaca_ RNF216 ( ortholog_one2one ) Alpaca_ RNF216 ( ortholog_one2many ) Dog_ RNF216 ( ortholog_one2one ) GuineaPig_ RNF216 ( ortholog_one2one ) Macaque_ RNF216 ( ortholog_one2one ) Mouse_ Rnf216 ( ortholog_one2one ) Pig_ RNF216 ( ortholog_one2one ) Rat_ Rnf216 ( ortholog_one2one ) Rabbit_ RNF216 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RBCK1, SHARPIN |
| Tissue | NA |
| Tissue Specificity | Ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7M4M (X-ray 2.39A ) 7M4N (X-ray 2.52A ) 7M4O (X-ray 2.21A ) |
| DBSNP | rs1335215379 rs387907368 |
| Subcellular location [CC] | Cytoplasm. |
| Mouse PG classification | NA |
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