| Gene Information | |
|---|---|
| Gene Name | PPP1CA |
| Organism | Homo sapiens (Human) |
| Gene Length | 330 |
| Protein Names | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) |
| Target Name | serine/threonine-protein phosphatase pp1-alpha catalytic subunit |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000172531 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P62136 |
| Gene Card | PPP1CA |
| Uniprot ID | P62136 |
| Pfam | PF00149; PF16891 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000096815) |
| Ortholog in Animals | Alpaca_ PPP1CA ( ortholog_one2one ) Dog_ PPP1CA ( ortholog_one2one ) GuineaPig_ PPP1CA ( ortholog_one2one ) Macaque_ PPP1CA ( ortholog_one2one ) Mouse_ Ppp1ca ( ortholog_one2one ) Pig_ PPP1CA ( ortholog_one2one ) Rat_ Ppp1ca ( ortholog_one2one ) Rabbit_ PPP1CA ( ortholog_one2one ) |
| Ohnologs | PPP1CC |
| Paralogs | PPP1CC, PPP3CC, PPP3CB, PPP6C, PPP5C, PPP2CB, PPP2CA, PPEF2, PPP4C, PPP3CA, PPEF1, PPP1CB |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.011607(Rat);0.094194(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3E7A (X-ray 1.63A ) 3E7B (X-ray 1.70A ) 3EGG (X-ray 1.85A ) 3EGH (X-ray 2.00A ) 3HVQ (X-ray 2.20A ) 3N5U (X-ray 3.20A ) 3V4Y (X-ray 2.10A ) 4G9J (X-ray 3.10A ) 4MOV (X-ray 1.45A ) 4MOY (X-ray 2.20A ) 4MP0 (X-ray 2.10A ) 4XPN (X-ray 2.29A ) 5IOH (X-ray 2.57A ) 6ALZ (X-ray 2.21A ) 6CZO (X-ray 2.95A ) 6DCX (X-ray 3.41A ) 6DNO (X-ray 1.45A ) 6G0I (X-ray 2.00A ) 6G0J (X-ray 2.10A ) 6GHM (X-ray 2.15A ) 6OBN (X-ray 2.70A ) 6OBP (X-ray 2.70A ) 6OBQ (X-ray 1.84A ) 6OBR (X-ray 1.50A ) 6OBS (X-ray 1.80A ) 6OBU (X-ray 1.95A ) 6ZEE (X-ray 1.90A ) 6ZEF (X-ray 1.94A ) 6ZEG (X-ray 1.09A ) 6ZEH (X-ray 1.30A ) 6ZEI (X-ray 1.39A ) 6ZEJ (X-ray 1.78A ) 6ZK6 (X-ray 1.90A ) 7TVF (X-ray 2.17A ) 7TXH (X-ray 1.95A ) 7UPI (EM 2.89A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:29769351}. Nucleus {ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:17965019}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:17965019}. Nucleus, nucleolus {ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:17965019}. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. Shuttles toward the cytosol during infection with VEEV (PubMed:29769351). {ECO:0000269|PubMed:29769351}. |
| Mouse PG classification | NA |
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