| Gene Information | |
|---|---|
| Gene Name | NEXN |
| Organism | Homo sapiens (Human) |
| Gene Length | 675 |
| Protein Names | Nexilin (F-actin-binding protein) (Nelin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000162614 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q0ZGT2 |
| Gene Card | NEXN |
| Uniprot ID | Q0ZGT2 |
| Pfam | PF07679 |
| In ASD | no |
| Allosteric Prediction | no (-0.801081663) |
| Ortholog in Animals | Alpaca_ NEXN ( ortholog_one2one ) Dog_ NEXN ( ortholog_one2one ) GuineaPig_ NEXN ( ortholog_one2one ) Macaque_ NEXN ( ortholog_one2one ) Mouse_ Nexn ( ortholog_one2one ) Pig_ NEXN ( ortholog_one2one ) Rat_ Nexn ( ortholog_one2one ) Rabbit_ NEXN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DAPK1, DAPK2, DAPK3, MYLK |
| Tissue | left.atrium, left.ventricle, pulmonary.valve |
| Tissue Specificity | Abundantly expressed in heart and skeletal muscle, and at lower levels in placenta, lung, liver and pancreas. Also expressed in HeLaS3 and MOLT-4 cell lines. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs387907079 rs1166698 rs146245480 rs9660322 rs137853198 rs137853197 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Z2J4}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9Z2J4}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q9Z2J4}. Note=Localizes to the cell-matrix AJ. Not found at the cell-cell AJ. {ECO:0000250|UniProtKB:Q9Z2J4}. |
| Mouse PG classification | HPG |
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