| Gene Information | |
|---|---|
| Gene Name | AMT |
| Organism | Homo sapiens (Human) |
| Gene Length | 403 |
| Protein Names | Aminomethyltransferase, mitochondrial (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT) |
| Target Name | aminomethyltransferase, mitochondrial |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000145020 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P48728 |
| Gene Card | AMT |
| Uniprot ID | P48728 |
| Pfam | PF01571; PF08669 |
| In ASD | no |
| Allosteric Prediction | yes (0.103385173) |
| Ortholog in Animals | Alpaca_ AMT ( ortholog_one2one ) Dog_ AMT ( ortholog_one2many ) GuineaPig_ AMT ( ortholog_one2one ) Macaque_ AMT ( ortholog_one2one ) Mouse_ Amt ( ortholog_one2one ) Pig_ AMT ( ortholog_one2one ) Rat_ Amt ( ortholog_one2many ) Rabbit_ AMT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | YPEL3, YPEL2, DMGDH, YPEL4, L2HGDH, PDPR, SARDH, FOXRED1, YPEL1, YPEL5 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WSR (X-ray 2.00A ) 1WSV (X-ray 2.60A ) |
| DBSNP | rs121964983 rs121964982 rs1126422 rs386833682 rs116192290 rs781466698 rs779483959 rs121964981 rs121964984 rs1056820947 rs121964985 |
| Subcellular location [CC] | Mitochondrion {ECO:0000305|PubMed:16051266}. |
| Mouse PG classification | NA |
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