| Gene Information | |
|---|---|
| Gene Name | RGS12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1447 |
| Protein Names | Regulator of G-protein signaling 12 (RGS12) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000159788 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O14924 |
| Gene Card | RGS12 |
| Uniprot ID | O14924 |
| Pfam | PF02188; PF00595; PF02196; PF00615 |
| In ASD | no |
| Allosteric Prediction | no (-0.268573957) |
| Ortholog in Animals | Alpaca_ RGS12 ( ortholog_one2many ) Dog_ RGS12 ( ortholog_one2one ) GuineaPig_ RGS12 ( ortholog_one2one ) Macaque_ RGS12 ( ortholog_one2one ) Mouse_ Rgs12 ( ortholog_one2one ) Pig_ RGS12 ( ortholog_one2one ) Rat_ Rgs12 ( ortholog_one2one ) |
| Ohnologs | RGS14 |
| Paralogs | RGS18, RGS5, RGS3, RGS20, RGS2, RGSL1, RGS21, AXIN1, RGS1, RGS11, RGS17, RGS7, RGS14, AXIN2, RGS22, RGS4, RGS6, RGS9, RGS13, RGS19, RGS8, RGS16, RGS10 |
| Tissue | NA |
| Tissue Specificity | Isoform 3 is brain specific. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2EBZ (NMR - ) 2KV8 (NMR - ) |
| DBSNP | rs7679941 rs16844152 rs2269497 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10869340}. Cytoplasm {ECO:0000250|UniProtKB:O08774}. Cell projection, dendrite {ECO:0000250|UniProtKB:O08774}. Synapse {ECO:0000250|UniProtKB:O08774}.; [Isoform 5]: Nucleus matrix {ECO:0000269|PubMed:12024043}. Note=Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains. {ECO:0000269|PubMed:12024043}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |