| Gene Information | |
|---|---|
| Gene Name | MSTN |
| Organism | Homo sapiens (Human) |
| Gene Length | 375 |
| Protein Names | Growth/differentiation factor 8 (GDF-8) (Myostatin) |
| Target Name | growth/differentiation factor 8 |
| Target Type | Clinical trial target |
| Gene Age | 424 ( ENSG00000138379 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O14793 |
| Gene Card | MSTN |
| Uniprot ID | O14793 |
| Pfam | PF00019; PF00688 |
| In ASD | no |
| Allosteric Prediction | yes (0.29991948) |
| Ortholog in Animals | Alpaca_ MSTN ( ortholog_one2one ) Dog_ MSTN ( ortholog_one2one ) GuineaPig_ MSTN ( ortholog_one2one ) Macaque_ MSTN ( ortholog_one2one ) Mouse_ Mstn ( ortholog_one2one ) Pig_ MSTN ( ortholog_one2one ) Rat_ Mstn ( ortholog_one2one ) Rabbit_ MSTN ( ortholog_one2one ) |
| Ohnologs | GDF11 |
| Paralogs | BMP3, INHBC, GDF15, BMP6, INHBA, GDF6, TGFB3, BMP2, BMP10, TGFB1, INHA, GDF9, GDF11, BMP5, BMP7, INHBB, GDF5, GDF1, GDF2, BMP4, LEFTY1, LEFTY2, GDF3, INHBE, GDF7, GDF10, BMP15, TGFB2, BMP8A, BMP8B, NODAL |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5F3B (X-ray 1.76A ) 5F3H (X-ray 2.70A ) 5NTU (X-ray 2.58A ) 5NXS (X-ray 4.19A ) 6UMX (X-ray 2.79A ) |
| DBSNP | rs1805085 rs1805086 rs34780010 rs16823988 |
| Subcellular location [CC] | Secreted {ECO:0000250|UniProtKB:O08689}. |
| Mouse PG classification | NA |
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