| Gene Information | |
|---|---|
| Gene Name | SERINC5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 423 |
| Protein Names | Serine incorporator 5 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000164300 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86VE9 |
| Gene Card | SERINC5 |
| Uniprot ID | Q86VE9 |
| Pfam | PF03348 |
| In ASD | no |
| Allosteric Prediction | no (-0.61088486) |
| Ortholog in Animals | Alpaca_ SERINC5 ( ortholog_one2one ) Dog_ SERINC5 ( ortholog_one2one ) GuineaPig_ SERINC5 ( ortholog_one2one ) Macaque_ SERINC5 ( ortholog_one2one ) Mouse_ Serinc5 ( ortholog_one2one ) Pig_ SERINC5 ( ortholog_one2one ) Rat_ Serinc5 ( ortholog_one2one ) Rabbit_ SERINC5 ( ortholog_one2one ) |
| Ohnologs | SERINC4 |
| Paralogs | SERINC4, SERINC1, SERINC2, SERINC3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte and is expressed weakly in the heart, liver and fetal brain. {ECO:0000269|PubMed:12688535}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}; Multi-pass membrane protein {ECO:0000255}.; Cytoplasm, perinuclear region {ECO:0000269|PubMed:26416734, ECO:0000305|PubMed:26416733}. Note=(Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-1 Nef, excluding it from virions particles, thereby preventing subsequent antiviral defense activity (PubMed:26416733, PubMed:26416734). Localizes to the cell membrane, where it is efficiently incorporated into budding virions and impairs subsequent virion entry into target cells (PubMed:26416733, PubMed:26416734). {ECO:0000269|PubMed:26416734, ECO:0000305|PubMed:26416733}. |
| Mouse PG classification | NA |
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