| Gene Information | |
|---|---|
| Gene Name | MST1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 487 |
| Protein Names | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000173531 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q13043 |
| Gene Card | STK4 |
| Uniprot ID | Q13043 |
| Pfam | PF11629; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.762216285) |
| Ortholog in Animals | Alpaca_ MST1 ( ortholog_one2one ) Dog_ MST1 ( ortholog_one2one ) GuineaPig_ MST1 ( ortholog_one2one ) Macaque_ MST1 ( ortholog_one2one ) Mouse_ Mst1 ( ortholog_one2one ) Pig_ MST1 ( ortholog_one2one ) Rat_ Mst1 ( ortholog_one2one ) Rabbit_ MST1 ( ortholog_one2one ) |
| Ohnologs | HGF |
| Paralogs | GZMA, PIK3IP1, HABP2, GZMK, HGF |
| Tissue | NA |
| Tissue Specificity | Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Ubiquitously expressed. {ECO:0000269|PubMed:17932490}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.101296(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2JO8 (NMR - ) 3COM (X-ray 2.20A ) 4NR2 (X-ray 2.00A ) 4OH8 (X-ray 2.28A ) 5TWG (X-ray 2.30A ) 5TWH (X-ray 2.50A ) 6YAT (X-ray 2.58A ) 8A5J (X-ray 2.12A ) |
| DBSNP | rs55850759 rs35447878 rs17420378 rs35944046 rs33963346 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm. |
| Mouse PG classification | NA |
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