| Gene Information | |
|---|---|
| Gene Name | MSR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 451 |
| Protein Names | Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD antigen CD204) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000038945 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P21757 |
| Gene Card | MSR1 |
| Uniprot ID | P21757 |
| Pfam | PF01391; PF03523; PF00530 |
| In ASD | no |
| Allosteric Prediction | no (-0.227535871) |
| Ortholog in Animals | Alpaca_ MSR1 ( ortholog_one2one ) Dog_ MSR1 ( ortholog_one2one ) GuineaPig_ MSR1 ( ortholog_one2one ) Macaque_ MSR1 ( ortholog_one2one ) Mouse_ Msr1 ( ortholog_one2one ) Pig_ MSR1 ( ortholog_one2one ) Rat_ Msr1 ( ortholog_one2one ) Rabbit_ MSR1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SCARA5, COLEC12, MARCO |
| Tissue | lung |
| Tissue Specificity | Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages. Isoform I and isoform II are expressed in the liver, placenta and brain. {ECO:0000269|PubMed:2251254, ECO:0000269|PubMed:9548586}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7DPX (X-ray 2.00A ) |
| DBSNP | rs35175081 rs749666450 rs145597376 rs117359034 rs72552387 rs387906645 rs13306543 rs2229388 rs776370129 rs138749399 |
| Subcellular location [CC] | Membrane; Single-pass type II membrane protein. |
| Mouse PG classification | LPG |
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