| Gene Information | |
|---|---|
| Gene Name | MSN |
| Organism | Homo sapiens (Human) |
| Gene Length | 577 |
| Protein Names | Moesin (Membrane-organizing extension spike protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000147065 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P26038 |
| Gene Card | MSN |
| Uniprot ID | P26038 |
| Pfam | PF00769; PF20492; PF09380; PF00373; PF09379 |
| In ASD | no |
| Allosteric Prediction | yes (0.399393295) |
| Ortholog in Animals | Alpaca_ MSN ( ortholog_one2one ) Dog_ MSN ( ortholog_one2one ) GuineaPig_ MSN ( ortholog_one2one ) Macaque_ MSN ( ortholog_one2one ) Mouse_ Msn ( ortholog_one2one ) Pig_ MSN ( ortholog_one2one ) Rat_ Msn ( ortholog_one2one ) |
| Ohnologs | EZR, RDX |
| Paralogs | RDX, EZR, FRMD4B, NF2, ERMN, FRMD4A |
| Tissue | lung, mitral.valve |
| Tissue Specificity | In all tissues and cultured cells studied. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.017391(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1E5W (X-ray 2.70A ) 1EF1 (X-ray 1.90A ) 1SGH (X-ray 3.50A ) 6TXQ (X-ray 1.73A ) 6TXS (X-ray 2.20A ) |
| DBSNP | rs1057519074 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11728332, ECO:0000269|PubMed:15039356, ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:7884872, ECO:0000269|PubMed:9298994}; Peripheral membrane protein {ECO:0000250|UniProtKB:P26041}; Cytoplasmic side {ECO:0000250|UniProtKB:P26041}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P26041}. Apical cell membrane {ECO:0000250|UniProtKB:P26041}; Peripheral membrane protein {ECO:0000250|UniProtKB:P26041}; Cytoplasmic side {ECO:0000250|UniProtKB:P26041}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:P26041}; Peripheral membrane protein {ECO:0000250|UniProtKB:P26041}; Cytoplasmic side {ECO:0000250|UniProtKB:P26041}. Cell projection, microvillus {ECO:0000250|UniProtKB:P26041}. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane. Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment (By similarity). Localizes at the uropods of T lymphoblasts. {ECO:0000250|UniProtKB:P26041, ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:9298994}. |
| Mouse PG classification | NA |
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