| Gene Information | |
|---|---|
| Gene Name | MSK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 802 |
| Protein Names | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O75582 |
| Gene Card | RPS6KA5 |
| Uniprot ID | O75582 |
| Pfam | PF00069; PF00433 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver. {ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1VZO (X-ray 1.80A ) 3KN5 (X-ray 2.40A ) 3KN6 (X-ray 2.00A ) 7UP4 (X-ray 3.00A ) 7UP5 (X-ray 2.80A ) 7UP6 (X-ray 2.60A ) 7UP7 (X-ray 2.80A ) 7UP8 (X-ray 2.90A ) |
| DBSNP | rs34699345 rs55911249 rs34604933 rs55968863 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid. |
| Mouse PG classification | NA |
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