| Gene Information | |
|---|---|
| Gene Name | MSH6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1360 |
| Protein Names | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000116062 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P52701 |
| Gene Card | MSH6 |
| Uniprot ID | P52701 |
| Pfam | PF01624; PF05188; PF05192; PF05190; PF00488; PF00855 |
| In ASD | no |
| Allosteric Prediction | yes (0.243464497) |
| Ortholog in Animals | Alpaca_ MSH6 ( ortholog_one2one ) Dog_ MSH6 ( ortholog_one2one ) GuineaPig_ MSH6 ( ortholog_one2one ) Macaque_ MSH6 ( ortholog_one2one ) Mouse_ Msh6 ( ortholog_one2one ) Pig_ MSH6 ( ortholog_one2one ) Rat_ Msh6 ( ortholog_one2one ) Rabbit_ MSH6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MSH3, MSH2, MSH5, MSH4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.059889(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2GFU (NMR - ) 2O8B (X-ray 2.75A ) 2O8C (X-ray 3.37A ) 2O8D (X-ray 3.00A ) 2O8E (X-ray 3.30A ) 2O8F (X-ray 3.25A ) 6OQM (X-ray 2.20A ) |
| DBSNP | rs41294988 rs63750664 rs267608026 rs35462442 rs1042821 rs63751098 rs41294984 rs63751258 rs63750143 rs3211299 rs1800938 rs41557217 rs63750878 rs267608051 rs587779323 rs61753793 rs2020908 rs63751405 rs63750741 rs41295268 rs61754783 rs63750897 rs63751005 rs63751009 rs728619 rs63749973 rs41295270 rs587779220 rs201735525 rs63751121 rs3136334 rs63750462 rs587779224 rs63750358 rs63750832 rs63750304 rs35552856 rs63750725 rs63750138 rs63750637 rs63750895 rs61748083 rs63751450 rs63750389 rs34374438 rs2020912 rs2020914 rs63749889 rs63751113 rs63750287 rs267608054 rs63750804 rs63750617 rs63750753 rs63750998 rs63750998 rs63750253 rs63750442 rs63750157 rs63750252 rs63751328 rs63750949 rs63750370 rs41295276 rs35717727 rs63750882 rs63750673 rs63750836 rs41295278 rs267608140 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:23622243}. Chromosome {ECO:0000269|PubMed:23622243}. Note=Associates with H3K36me3 via its PWWP domain. |
| Mouse PG classification | HPG |
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