| Gene Information | |
|---|---|
| Gene Name | MDH2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 338 |
| Protein Names | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) |
| Target Name | malate dehydrogenase, mitochondrial |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000146701 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P40926 |
| Gene Card | MDH2 |
| Uniprot ID | P40926 |
| Pfam | PF02866; PF00056 |
| In ASD | no |
| Allosteric Prediction | yes (0.821143397) |
| Ortholog in Animals | Alpaca_ MDH2 ( ortholog_one2one ) Dog_ MDH2 ( ortholog_one2many ) GuineaPig_ MDH2 ( ortholog_one2one ) Macaque_ MDH2 ( ortholog_one2one ) Mouse_ Mdh2 ( ortholog_one2one ) Pig_ MDH2 ( ortholog_one2one ) Rat_ Mdh2 ( ortholog_one2one ) Rabbit_ MDH2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LDHB, LDHAL6B, LDHC, LDHA, LDHAL6A |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DFD (X-ray 1.90A ) 4WLE (X-ray 1.90A ) 4WLF (X-ray 2.20A ) 4WLN (X-ray 2.28A ) 4WLO (X-ray 2.50A ) 4WLU (X-ray 2.14A ) 4WLV (X-ray 2.40A ) |
| DBSNP | rs6720 rs782308462 rs375002796 rs1057519566 |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000250|UniProtKB:P04636}. |
| Mouse PG classification | NA |
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