| Gene Information | |
|---|---|
| Gene Name | MRP5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1437 |
| Protein Names | ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O15440 |
| Gene Card | ABCC5 |
| Uniprot ID | O15440 |
| Pfam | PF00664; PF00005 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | [Isoform 3]: Predominant isoform in retinal pigment epithelium, bladder, and stomach. {ECO:0000269|PubMed:17521428}.; Ubiquitously expressed, but levels in brain and muscle are especially high (PubMed:9827529, PubMed:10438534, PubMed:15501592). All isoforms are equally expressed in retina (PubMed:17521428). {ECO:0000269|PubMed:10438534, ECO:0000269|PubMed:15501592, ECO:0000269|PubMed:17521428, ECO:0000269|PubMed:9827529}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Basolateral cell membrane {ECO:0000269|PubMed:24836561}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus lumen {ECO:0000269|PubMed:24836561}. Endosome membrane {ECO:0000269|PubMed:24836561}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q9R1X5}. Apical cell membrane {ECO:0000269|PubMed:15501592}; Multi-pass membrane protein {ECO:0000255}. Note=In most cells, routes to the basolateral plasma membrane, but in the brain capillary endothelial cells that form the blood-brain barrier, resides in the apical membrane. {ECO:0000269|PubMed:15501592, ECO:0000269|PubMed:24836561}. |
| Mouse PG classification | NA |
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