| Gene Information | |
|---|---|
| Gene Name | ZDHHC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 485 |
| Protein Names | Palmitoyltransferase ZDHHC1 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 1) (Zinc finger DHHC domain-containing protein 1) (DHHC-1) (Zinc finger protein 377) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000159714 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8WTX9 |
| Gene Card | ZDHHC1 |
| Uniprot ID | Q8WTX9 |
| Pfam | PF01529 |
| In ASD | no |
| Allosteric Prediction | no (-1.090685256) |
| Ortholog in Animals | Alpaca_ ZDHHC1 ( ortholog_one2one ) Dog_ ZDHHC1 ( ortholog_one2one ) GuineaPig_ ZDHHC1 ( ortholog_one2one ) Macaque_ ZDHHC1 ( ortholog_one2one ) Mouse_ Zdhhc1 ( ortholog_one2one ) Pig_ ZDHHC1 ( ortholog_one2one ) Rat_ Zdhhc1 ( ortholog_one2one ) Rabbit_ ZDHHC1 ( ortholog_one2one ) |
| Ohnologs | ZDHHC11, ZDHHC11B |
| Paralogs | ZDHHC6, ZDHHC21, ZDHHC7, ZDHHC20, ZDHHC2, ZDHHC12, ZDHHC18, ZDHHC23, ZDHHC4, ZDHHC9, ZDHHC22, ZDHHC11, ZDHHC11B, ZDHHC3, ZDHHC15, ZDHHC14, ZDHHC19 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with significant expression in heart, brain, placenta, lung, liver, kidney, testis, thymus and small intestine (PubMed:16647879). Expressed at lower levels in adult pancreas and lung (PubMed:10395086). {ECO:0000269|PubMed:10395086, ECO:0000269|PubMed:16647879}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34229857 |
| Subcellular location [CC] | Endosome membrane {ECO:0000250|UniProtKB:Q8R0N9}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:16647879, ECO:0000269|PubMed:25299331}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000269|PubMed:25299331}. |
| Mouse PG classification | NA |
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