| Gene Information | |
|---|---|
| Gene Name | MRGPRX4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 322 |
| Protein Names | Mas-related G-protein coupled receptor member X4 (Sensory neuron-specific G-protein coupled receptor 5/6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000179817 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q96LA9 |
| Gene Card | MRGPRX4 |
| Uniprot ID | Q96LA9 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | no (-0.21114439) |
| Ortholog in Animals | Alpaca_ MRGPRX4 ( ortholog_one2one ) Macaque_ MRGPRX4 ( ortholog_one2one ) Mouse_ Mrgprb8 ( ortholog_many2many ) Mouse_ Mrgprb1 ( ortholog_many2many ) Mouse_ Mrgpra2b ( ortholog_many2many ) Mouse_ Mrgpra6 ( ortholog_many2many ) Mouse_ Mrgprb3 ( ortholog_many2many ) Mouse_ Mrgprx2 ( ortholog_many2many ) Mouse_ Mrgpra2a ( ortholog_many2many ) Mouse_ Mrgpra4 ( ortholog_many2many ) Mouse_ Mrgpra9 ( ortholog_many2many ) Mouse_ Mrgpra1 ( ortholog_many2many ) Mouse_ Mrgprb4 ( ortholog_many2many ) Mouse_ Mrgprb2 ( ortholog_many2many ) Mouse_ Mrgprx1 ( ortholog_many2many ) Mouse_ Mrgprb5 ( ortholog_many2many ) Mouse_ Mrgpra3 ( ortholog_many2many ) Rat_ Mrgprx3 ( ortholog_many2many ) Rat_ Mrgprb4 ( ortholog_many2many ) Rat_ Mrgprb13 ( ortholog_many2many ) Rat_ Mrgprb3 ( ortholog_many2many ) Rat_ Mrgprb5 ( ortholog_many2many ) Rat_ Mrgprx4 ( ortholog_many2many ) Rat_ Mrgprx1 ( ortholog_many2many ) Rabbit_ MGRG2 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | MRGPRX3, MRGPRX1, MRGPRX2, MRGPRE, MRGPRG, MAS1L, MRGPRD, MRGPRF, MAS1, GPR152 |
| Tissue | NA |
| Tissue Specificity | Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. {ECO:0000269|PubMed:11850634}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7S8P (EM 2.60A ) |
| DBSNP | rs2468774 rs2445180 rs1869788 rs2445179 rs11024532 rs7102322 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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