| Gene Information | |
|---|---|
| Gene Name | MRGPRX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 330 |
| Protein Names | Mas-related G-protein coupled receptor member X2 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000183695 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q96LB1 |
| Gene Card | MRGPRX2 |
| Uniprot ID | Q96LB1 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | no (-0.190585881) |
| Ortholog in Animals | Alpaca_ MRGPRX2 ( ortholog_one2one ) Mouse_ Mrgprb8 ( ortholog_many2many ) Mouse_ Mrgprb1 ( ortholog_many2many ) Mouse_ Mrgpra2b ( ortholog_many2many ) Mouse_ Mrgpra6 ( ortholog_many2many ) Mouse_ Mrgprb3 ( ortholog_many2many ) Mouse_ Mrgprx2 ( ortholog_many2many ) Mouse_ Mrgpra2a ( ortholog_many2many ) Mouse_ Mrgpra4 ( ortholog_many2many ) Mouse_ Mrgpra9 ( ortholog_many2many ) Mouse_ Mrgpra1 ( ortholog_many2many ) Mouse_ Mrgprb4 ( ortholog_many2many ) Mouse_ Mrgprb2 ( ortholog_many2many ) Mouse_ Mrgprx1 ( ortholog_many2many ) Mouse_ Mrgprb5 ( ortholog_many2many ) Mouse_ Mrgpra3 ( ortholog_many2many ) Rat_ Mrgprx3 ( ortholog_many2many ) Rat_ Mrgprb4 ( ortholog_many2many ) Rat_ Mrgprb13 ( ortholog_many2many ) Rat_ Mrgprb3 ( ortholog_many2many ) Rat_ Mrgprb5 ( ortholog_many2many ) Rat_ Mrgprx4 ( ortholog_many2many ) Rat_ Mrgprx1 ( ortholog_many2many ) Rabbit_ MGRG2 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | MRGPRX3, MRGPRX4, MRGPRX1, MRGPRE, MRGPRG, MAS1L, MRGPRD, MRGPRF, MAS1, GPR152 |
| Tissue | NA |
| Tissue Specificity | Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion (PubMed:12915402). Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protein level) (PubMed:16161007). {ECO:0000269|PubMed:12915402, ECO:0000269|PubMed:16161007}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 7S8L (EM 2.45A ) 7S8M (EM 2.54A ) 7S8N (EM 2.90A ) 7S8O (EM 2.58A ) 7VDH (EM 2.90A ) 7VDL (EM 3.22A ) 7VDM (EM 2.98A ) 7VUY (EM 2.84A ) 7VUZ (EM 2.89A ) 7VV0 (EM 3.50A ) 7VV3 (EM 2.97A ) 7VV4 (EM 2.97A ) 7VV5 (EM 2.76A ) 7VV6 (EM 3.30A ) |
| DBSNP | rs11024970 rs11823569 rs10833049 rs79763999 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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