| Gene Information | |
|---|---|
| Gene Name | MRF |
| Organism | Homo sapiens (Human) |
| Gene Length | 1151 |
| Protein Names | Myelin regulatory factor (EC 3.4.-.-) (Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9Y2G1 |
| Gene Card | MYRF |
| Uniprot ID | Q9Y2G1 |
| Pfam | PF13888; PF13887; PF05224; PF13884 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in lung, ARPE-19 cell line, brainstem, uterus and, to a lesser extent, in basal ganglion and liver. Weakly expressed in cerebellum and retina. {ECO:0000269|PubMed:10828591}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5YHU (X-ray 1.85A ) 5ZHU (X-ray 2.20A ) |
| DBSNP | rs1565295286 rs1565295550 rs1382225004 rs34038946 |
| Subcellular location [CC] | [Myelin regulatory factor]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23966832}; Single-pass membrane protein.; [Myelin regulatory factor, N-terminal]: Nucleus {ECO:0000269|PubMed:23966832}. Cytoplasm {ECO:0000269|PubMed:23966832}. Note=Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage. {ECO:0000269|PubMed:23966832}.; [Myelin regulatory factor, C-terminal]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23966832}; Single-pass membrane protein {ECO:0000269|PubMed:23966832}. |
| Mouse PG classification | NA |
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