Gene Information
Gene NameDMPK
OrganismHomo sapiens (Human)
Gene Length629
Protein NamesMyotonin-protein kinase (MT-PK) (EC 2.7.11.1) (DM-kinase) (DMK) (DM1 protein kinase) (DMPK) (Myotonic dystrophy protein kinase)
Target Namedmpk messenger rna
Target TypeClinical trial target
Gene Age382 ( ENSG00000104936 )
Evolutionary StageEukaryota
AlphaFoldDBQ09013
Gene CardDMPK
Uniprot IDQ09013
PfamPF08826; PF00069
In ASDno
Allosteric Predictionyes (0.4759988)
Ortholog in AnimalsAlpaca_ DMPK ( ortholog_one2one )
Dog_ DMPK ( ortholog_one2one )
GuineaPig_ DMPK ( ortholog_one2one )
Mouse_ Dmpk ( ortholog_one2one )
Pig_ DMPK ( ortholog_one2one )
Rat_ Dmpk ( ortholog_one2one )
OhnologsNA
ParalogsSTK32B, MAST3, STK32A, MAST2, LATS2, SGK1, MAST4, SGK2, SGK3, LATS1, STK32C, MAST1, MASTL
TissueNA
Tissue SpecificityMost isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons. {ECO:0000269|PubMed:7488138}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1WT6  (X-ray  1.60A  )  2VD5  (X-ray  2.80A  ) 
DBSNP rs527221 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000250};
Single-pass type IV membrane protein {ECO:0000250};
Cytoplasmic side {ECO:0000250}. Nucleus outer membrane {ECO:0000305};
Single-pass type IV membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Mitochondrion outer membrane {ECO:0000305};
Single-pass type IV membrane protein {ECO:0000305}. Sarcoplasmic reticulum membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Localizes to sarcoplasmic reticulum membranes of cardiomyocytes. {ECO:0000250}.;
[Isoform 1]: Mitochondrion membrane.;
[Isoform 3]: Mitochondrion membrane.
Mouse PG classificationLPG
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