| Gene Information | |
|---|---|
| Gene Name | MRAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 172 |
| Protein Names | Melanocortin-2 receptor accessory protein (B27) (Fat cell-specific low molecular weight protein) (Fat tissue-specific low MW protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000170262 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q8TCY5 |
| Gene Card | MRAP |
| Uniprot ID | Q8TCY5 |
| Pfam | PF15183 |
| In ASD | no |
| Allosteric Prediction | no (-0.012040272) |
| Ortholog in Animals | Alpaca_ MRAP ( ortholog_one2one ) Macaque_ MRAP ( ortholog_one2one ) Mouse_ Mrap ( ortholog_one2one ) Rat_ Mrap ( ortholog_one2one ) Rabbit_ MRAP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | adipose.tissue, adrenal.gland |
| Tissue Specificity | Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues. {ECO:0000269|PubMed:15654338}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.005990(Rat);0.100000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15654338}; Single-pass membrane protein {ECO:0000269|PubMed:15654338}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15654338}; Single-pass membrane protein {ECO:0000269|PubMed:15654338}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771). Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm. {ECO:0000269|PubMed:20371771}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |