Gene Information
Gene NameMR1
OrganismHomo sapiens (Human)
Gene Length341
Protein NamesMajor histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein)
Target Namemajor histocompatibility complex class i-related gene protein
Target TypeNA
Gene Age544 ( ENSG00000153029 )
Evolutionary StageVertebrata
AlphaFoldDBQ95460
Gene CardMR1
Uniprot IDQ95460
PfamPF07654; PF00129
In ASDno
Allosteric Predictionno (-0.938945019)
Ortholog in AnimalsAlpaca_ MR1 ( ortholog_one2one )
GuineaPig_ MR1 ( ortholog_one2one )
Macaque_ MR1 ( ortholog_one2one )
Mouse_ Mr1 ( ortholog_one2one )
Pig_ MR1 ( ortholog_one2one )
Rat_ Mr1 ( ortholog_one2one )
OhnologsNA
ParalogsHLA-B, HLA-E, HLA-A, HLA-F, HLA-G, HLA-C, CD1B, ULBP2, RAET1L, FCGRT, RAET1G, CD1A, CD1D, CD1C, RAET1E, ULBP3, ULBP1, CD1E, AZGP1, MICA, HFE, MICB
TissueNA
Tissue SpecificityUbiquitous (PubMed:7624800, PubMed:9780177). Low expression is detected in peripheral blood B cells, T cells, monocytes and in bronchial epithelial cells (at protein level) (PubMed:27043408). Expressed in plasmablasts or plasma B cells in the lamina propria of ileum, appendix and colon (at protein level) (PubMed:19760593). Highly expressed on a subset of CD45-positive CD3-positive thymocytes (at protein level) (PubMed:22692454). {ECO:0000269|PubMed:19760593, ECO:0000269|PubMed:22692454, ECO:0000269|PubMed:27043408, ECO:0000269|PubMed:7624800, ECO:0000269|PubMed:9780177}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4GUP  (X-ray  3.20A  )  4L4T  (X-ray  2.00A  )  4L4V  (X-ray  1.90A  )  4LCW  (X-ray  2.40A  )  4NQC  (X-ray  2.50A  )  4NQD  (X-ray  2.20A  )  4NQE  (X-ray  2.10A  )  4PJ5  (X-ray  2.00A  )  4PJ7  (X-ray  2.50A  )  4PJ8  (X-ray  3.30A  )  4PJ9  (X-ray  2.00A  )  4PJA  (X-ray  2.68A  )  4PJB  (X-ray  2.85A  )  4PJC  (X-ray  2.50A  )  4PJD  (X-ray  2.78A  )  4PJE  (X-ray  1.95A  )  4PJF  (X-ray  2.45A  )  4PJG  (X-ray  2.40A  )  4PJH  (X-ray  2.00A  )  4PJI  (X-ray  2.50A  )  4PJX  (X-ray  2.25A  )  5D5M  (X-ray  2.20A  )  5D7I  (X-ray  2.00A  )  5D7J  (X-ray  1.97A  )  5D7L  (X-ray  3.40A  )  5U16  (X-ray  2.00A  )  5U17  (X-ray  2.15A  )  5U1R  (X-ray  2.70A  )  5U2V  (X-ray  2.20A  )  5U6Q  (X-ray  1.90A  )  5U72  (X-ray  2.50A  )  6MWR  (X-ray  3.30A  )  6PUC  (X-ray  1.85A  )  6PUD  (X-ray  1.80A  )  6PUE  (X-ray  1.90A  )  6PUF  (X-ray  1.92A  )  6PUG  (X-ray  1.80A  )  6PUH  (X-ray  1.88A  )  6PUI  (X-ray  1.96A  )  6PUJ  (X-ray  1.92A  )  6PUK  (X-ray  2.08A  )  6PUL  (X-ray  1.84A  )  6PUM  (X-ray  1.96A  )  6PVC  (X-ray  1.96A  )  6PVD  (X-ray  2.14A  )  6W9U  (X-ray  1.89A  )  6W9V  (X-ray  1.95A  )  6XQP  (X-ray  2.90A  )  7LLI  (X-ray  3.20A  )  7LLJ  (X-ray  3.15A  )  7RNO  (NMR  -  )  7UMG  (X-ray  2.40A  ) 
DBSNP rs2236410  rs3897433  rs3897434 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:12794138, ECO:0000269|PubMed:18068122, ECO:0000269|PubMed:27043408};
Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18068122, ECO:0000269|PubMed:27043408};
Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:18068122};
Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:27043408};
Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:18068122, ECO:0000269|PubMed:27043408};
Single-pass type I membrane protein {ECO:0000255}. Note=In the absence of antigen remains within the endoplasmic reticulum where it acts as a metabolite sensor. Antigen binding triggers trafficking of the ternary complex to the plasma membrane. After presentation, most of these complexes are rapidly internalized and degraded via endocytosis. A small subset recycles via endosomes back to the plasma membrane and may thus acquire and present new antigens that do not efficiently reach the endoplasmic reticulum. {ECO:0000269|PubMed:27043408}.;
[Isoform 1]: Cell membrane {ECO:0000269|PubMed:23457030};
Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23457030};
Single-pass membrane protein {ECO:0000255}.;
[Isoform 3]: Cell membrane {ECO:0000269|PubMed:23457030};
Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23457030};
Single-pass membrane protein {ECO:0000255}. Note=The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway. {ECO:0000269|PubMed:23457030}.;
[Isoform 4]: Secreted {ECO:0000303|PubMed:9780177}.
Mouse PG classificationNA
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