| Gene Information | |
|---|---|
| Gene Name | EPS8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 822 |
| Protein Names | Epidermal growth factor receptor kinase substrate 8 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000151491 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q12929 |
| Gene Card | EPS8 |
| Uniprot ID | Q12929 |
| Pfam | PF08416; PF18016; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (0.040035092) |
| Ortholog in Animals | Alpaca_ EPS8 ( ortholog_one2one ) Dog_ EPS8 ( ortholog_one2one ) GuineaPig_ EPS8 ( ortholog_one2one ) Macaque_ EPS8 ( ortholog_one2one ) Mouse_ Eps8 ( ortholog_one2one ) Pig_ EPS8 ( ortholog_one2one ) Rat_ Eps8 ( ortholog_one2one ) Rabbit_ EPS8 ( ortholog_one2one ) |
| Ohnologs | EPS8L2, EPS8L3 |
| Paralogs | EPS8L2, EPS8L3, EPS8L1 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2E8M (NMR - ) 7TZK (X-ray 1.43A ) |
| DBSNP | rs7137185 rs1802658 |
| Subcellular location [CC] | Cytoplasm, cell cortex {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, stereocilium {ECO:0000250, ECO:0000250|UniProtKB:Q08509}. Synapse, synaptosome {ECO:0000250}. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells (By similarity). Localizes to the midzone of dividing cells. {ECO:0000250, ECO:0000250|UniProtKB:Q08509}. |
| Mouse PG classification | NA |
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