| Gene Information | |
|---|---|
| Gene Name | MPZ |
| Organism | Homo sapiens (Human) |
| Gene Length | 248 |
| Protein Names | Myelin protein P0 (Myelin peripheral protein) (MPP) (Myelin protein zero) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000158887 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P25189 |
| Gene Card | MPZ |
| Uniprot ID | P25189 |
| Pfam | PF10570; PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.924637104) |
| Ortholog in Animals | Alpaca_ MPZ ( ortholog_one2one ) Dog_ MPZ ( ortholog_one2one ) GuineaPig_ MPZ ( ortholog_one2one ) Macaque_ MPZ ( ortholog_one2one ) Mouse_ Mpz ( ortholog_one2one ) Pig_ MPZ ( ortholog_one2one ) Rat_ Mpz ( ortholog_one2one ) Rabbit_ MPZ ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MPZL3, MPZL2, MPZL1, JAML, SCN2B, SCN4B |
| Tissue | tibial.nerve |
| Tissue Specificity | Found only in peripheral nervous system Schwann cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3OAI (X-ray 2.10A ) |
| DBSNP | rs770546306 rs121913596 rs371856018 rs121913598 rs1553259790 rs121913604 rs786204119 rs121913602 rs121913605 rs121913585 rs121913585 rs1553259760 rs121913597 rs121913601 rs121913601 rs121913594 rs281865123 rs1553259707 rs267607244 rs121913584 rs267607245 rs1060503418 rs121913583 rs121913606 rs121913590 rs121913589 rs121913589 rs121913600 rs1060503420 rs1553259662 rs281865126 rs267607241 rs267607242 rs879254038 rs121913595 rs121913595 rs267607243 rs281865127 rs121913599 rs1553259647 rs879253858 rs121913587 rs121913588 rs572010627 rs750724650 rs121913603 rs267607246 rs281865128 rs121913586 rs267607247 rs749722729 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18337304}; Single-pass type I membrane protein.; [Isoform L-MPZ]: Myelin membrane {ECO:0000269|PubMed:22457349}; Single-pass type I membrane protein {ECO:0000269|PubMed:22457349}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |