| Gene Information | |
|---|---|
| Gene Name | CTNNB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 781 |
| Protein Names | Catenin beta-1 (Beta-catenin) |
| Target Name | beta-catenin |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000168036 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P35222 |
| Gene Card | CTNNB1 |
| Uniprot ID | P35222 |
| Pfam | PF00514 |
| In ASD | no |
| Allosteric Prediction | yes (1.701582229) |
| Ortholog in Animals | Alpaca_ CTNNB1 ( ortholog_one2one ) Dog_ CTNNB1 ( ortholog_one2one ) GuineaPig_ CTNNB1 ( ortholog_one2one ) Macaque_ CTNNB1 ( ortholog_one2one ) Mouse_ Ctnnb1 ( ortholog_one2one ) Pig_ CTNNB1 ( ortholog_one2one ) Rat_ Ctnnb1 ( ortholog_one2one ) Rabbit_ CTNNB1 ( ortholog_one2one ) |
| Ohnologs | JUP |
| Paralogs | JUP, ANKAR, ARMC3, ODAD2 |
| Tissue | NA |
| Tissue Specificity | Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). Expressed in breast cancer tissues (at protein level) (PubMed:29367600). {ECO:0000269|PubMed:11703283, ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:17289029, ECO:0000269|PubMed:29367600}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1G3J (X-ray 2.10A ) 1JDH (X-ray 1.90A ) 1JPW (X-ray 2.50A ) 1LUJ (X-ray 2.50A ) 1P22 (X-ray 2.95A ) 1QZ7 (X-ray 2.20A ) 1T08 (X-ray 2.10A ) 1TH1 (X-ray 2.50A ) 2G57 (NMR - ) 2GL7 (X-ray 2.60A ) 2Z6H (X-ray 2.20A ) 3DIW (X-ray 2.10A ) 3FQN (X-ray 1.65A ) 3FQR (X-ray 1.70A ) 3SL9 (X-ray 2.20A ) 3SLA (X-ray 2.50A ) 3TX7 (X-ray 2.76A ) 4DJS (X-ray 3.03A ) 6M90 (X-ray 2.05A ) 6M91 (X-ray 2.40A ) 6M92 (X-ray 2.35A ) 6M93 (X-ray 2.50A ) 6M94 (X-ray 2.70A ) 6O9B (X-ray 2.20A ) 6O9C (X-ray 2.45A ) 6WLX (X-ray 2.20A ) 6WNX (X-ray 2.50A ) 7AFW (X-ray 1.81A ) 7AR4 (X-ray 2.60A ) |
| DBSNP | rs1413975856 rs121913396 rs121913396 rs28931588 rs121913400 rs121913400 rs28931589 rs121913399 rs28931589 rs121913228 rs121913403 rs121913403 rs121913403 rs121913412 rs121913413 rs121913409 rs121913407 rs4135384 rs748653573 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:25183871, ECO:0000269|PubMed:29739711, ECO:0000269|PubMed:31801859}. Nucleus {ECO:0000269|PubMed:24342833, ECO:0000269|PubMed:25183871, ECO:0000269|PubMed:28829046, ECO:0000269|PubMed:29367600, ECO:0000269|PubMed:29739711, ECO:0000269|PubMed:31801859}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:B6V8E6}. Cell junction, adherens junction {ECO:0000269|PubMed:10725230}. Cell junction {ECO:0000250|UniProtKB:B6V8E6}. Cell membrane {ECO:0000269|PubMed:11790773, ECO:0000269|PubMed:24342833}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Synapse {ECO:0000250|UniProtKB:Q02248}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q02248}. Note=Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity). Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Interaction with FAM53B promotes translocation to the nucleus (PubMed:25183871). {ECO:0000250|UniProtKB:B6V8E6, ECO:0000269|PubMed:25183871}. |
| Mouse PG classification | NA |
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