| Gene Information | |
|---|---|
| Gene Name | PLEKHM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1019 |
| Protein Names | Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000116786 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8IWE5 |
| Gene Card | PLEKHM2 |
| Uniprot ID | Q8IWE5 |
| Pfam | PF00169; PF02759 |
| In ASD | no |
| Allosteric Prediction | no (-0.827179573) |
| Ortholog in Animals | Alpaca_ PLEKHM2 ( ortholog_one2one ) Dog_ PLEKHM2 ( ortholog_one2one ) GuineaPig_ PLEKHM2 ( ortholog_one2one ) Macaque_ PLEKHM2 ( ortholog_one2one ) Mouse_ Plekhm2 ( ortholog_one2one ) Pig_ PLEKHM2 ( ortholog_one2one ) Rat_ Plekhm2 ( ortholog_one2one ) Rabbit_ PLEKHM2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RUFY1, PLEKHF1, ZFYVE1, ZFYVE26, ZFYVE28, RUNDC3B, RUFY2, RUFY3, RUNDC3A, ZFYVE16, PLEKHF2, SNX29, ZFYVE19 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3CXB (X-ray 2.60A ) 3HW2 (X-ray 3.30A ) 3ZFW (X-ray 2.90A ) |
| DBSNP | rs12091750 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15905402}. Lysosome membrane {ECO:0000269|PubMed:22172677}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:22172677}. |
| Mouse PG classification | NA |
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