| Gene Information | |
|---|---|
| Gene Name | MPRI |
| Organism | Homo sapiens (Human) |
| Gene Length | 2491 |
| Protein Names | Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P11717 |
| Gene Card | IGF2R |
| Uniprot ID | P11717 |
| Pfam | PF00878; PF00040 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002101(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1E6F (X-ray 1.75A ) 1GP0 (X-ray 1.40A ) 1GP3 (X-ray 1.95A ) 1GQB (X-ray 1.80A ) 1JPL (X-ray 2.40A ) 1JWG (X-ray 2.00A ) 1LF8 (X-ray 2.30A ) 2CNJ (NMR - ) 2L29 (NMR - ) 2L2A (NMR - ) 2M68 (NMR - ) 2M6T (NMR - ) 2V5N (X-ray 3.20A ) 2V5O (X-ray 2.91A ) 2V5P (X-ray 4.10A ) 5IEI (X-ray 2.80A ) 6N5X (X-ray 2.05A ) 6N5Y (X-ray 2.26A ) 6P8I (X-ray 2.54A ) 6V02 (X-ray 2.46A ) 6Z30 (X-ray 1.50A ) 6Z31 (X-ray 2.56A ) 6Z32 (X-ray 3.47A ) |
| DBSNP | rs8191704 rs8191746 rs8191753 rs8191754 rs8191758 rs8191776 rs6413489 rs8191797 rs6413491 rs8191808 rs8191819 rs8191842 rs8191843 rs8191844 rs2230043 rs8191859 rs8191860 rs2230048 rs629849 rs11552587 rs8191904 rs8191905 rs8191908 rs1805075 rs8191955 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:18817523}; Single-pass type I membrane protein {ECO:0000269|PubMed:2957598}. Endosome membrane {ECO:0000269|PubMed:18817523}; Single-pass type I membrane protein {ECO:0000269|PubMed:2957598}. Note=Mainly localized in the Golgi at steady state and not detectable in lysosome (PubMed:18817523). Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:18817523}. |
| Mouse PG classification | NA |
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